Malar Rash Systemic Lupus Erythematosus

Butterfly rash is also seen in other diseases such as pellagra dermatomyositis and bloom syndrome. In a patient with a malar rash a diagnosis of systemic lupus erythematosus should be considered and the examiner will want to question the patient further for symptoms of additional skin or other organ involvement including raynaud s phenomenon photosensitivity hair loss mouth ulcers and arthritis. It is regarded as the prototypal connective tissue disease 1 where the key pathogenesis relates to a dysfunctional immune system that results in over production of various autoantibodies.

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Clinical and laboratory findings in seventeen patients.

Malar rash systemic lupus erythematosus. About 25 of patients with chronic cutaneous le also have systemic le. Chronic cutaneous lupus erythematosus. Lupus is a somewhat rare condition likely underdiagnosed due to its. Patients with lupus have unusual antibodies in their blood that are targeted against their own body tissues.

Malar rash is frequently seen in systemic lupus erythematosus sle but is not a characteristic for a particular disease. In the united states the malar rash has been reported in 20 60 of patients in large lupus erythematosus cohorts while limited data suggest that the maculopapular eruption is present in 35 of patients with systemic lupus erythematosus sle. A malar rash is also known as a butterfly rash and appears on the face. It can occur alongside many conditions including lupus and rosacea.

J am acad dermatol. It is usually red or purple and may be blotchy or solid. Systemic lupus erythematosus sle is a chronic autoimmune disease characterised by multi system manifestations. Systemic lupus erythematosus sle is a multisystem autoimmune disease that predominantly affects women of childbearing age.

An autoimmune disease occurs when the body s tissues are attacked by its own immune system. Butterfly rash which is also known as malar rash is a medical manifestation consisting of a characteristic form of facial rash. Chronic cutaneous le accounts for 80 of presentations with cutaneous le. The exact cause is still unknown but hormonal and immunological influences as well as genetic predisposition are considered likely etiological factors.

Systemic lupus erythematosus in patients with chronic cutaneous discoid lupus erythematosus. A chronic inflammatory condition caused by an autoimmune disease. Malar rash is present in 50 to 60 percent of people with systemic lupus erythematosus also known as acute cutaneous lupus. The malar rash is believed to be associated with a younger age of disease onset.

Discoid le is the most common form of chronic cutaneous le. It is more prevalent in patients with skin of colour who are at greater risk of postinflammatory hyperpigmentation and hypertrophic scarring. Lupus can cause disease of the skin heart lungs kidneys joints and nervous system. Most of its pathology is mediated by either direct or indirect effects of these autoantibodies.